{"id":68,"date":"2022-12-25T23:25:00","date_gmt":"2022-12-25T20:25:00","guid":{"rendered":"https:\/\/kesikkalem.com\/index.php\/2022\/12\/25\/barrons-december-26-2022\/"},"modified":"2024-03-17T00:15:34","modified_gmt":"2024-03-16T21:15:34","slug":"barrons-december-26-2022","status":"publish","type":"post","link":"https:\/\/kesikkalem.com\/index.php\/2022\/12\/25\/barrons-december-26-2022\/","title":{"rendered":"Barron’s – December 26, 2022"},"content":{"rendered":"

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Vaccines Could Be Even Bigger in 2023 (A\u015f\u0131lar 2023’te Daha da B\u00fcy\u00fcyebilir)<\/span><\/b><\/p>\n


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Wall Street, salg\u0131n vurana kadar a\u015f\u0131 pazar\u0131n\u0131 b\u00fcy\u00fck \u00f6l\u00e7\u00fcde g\u00f6rmezden geldi. Bu y\u0131l, a\u015f\u0131lar\u0131n Covid-19 ile sava\u015fmaktan daha fazlas\u0131 oldu\u011funu g\u00f6sterecek.<\/b><\/span><\/p>\n


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JOSH NATHAN-KAZIS<\/b><\/span><\/p>\n

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Salg\u0131n\u0131n Wall Street’i a\u015f\u0131lardaki f\u0131rsatlara uyand\u0131rmas\u0131ndan bu yana \u00fc\u00e7 y\u0131l ge\u00e7ti. Yat\u0131r\u0131mc\u0131lar\u0131n i\u011fne cephesinde daha fazla b\u00fcy\u00fck haber aramas\u0131n\u0131n zaman\u0131 geldi ve her \u015fey Covid-19 ile ilgili de\u011fil. 2023’te ila\u00e7 \u015firketleri, RSV\u00b9 olarak bilinen solunum sinsityal vir\u00fcs\u00fc i\u00e7in ilk a\u015f\u0131lar\u0131 piyasaya s\u00fcrecek ve haberci RNA veya mRNA’ya dayal\u0131 ilk grip a\u015f\u0131s\u0131n\u0131 piyasaya s\u00fcrebilir. Ticari olarak piyasaya \u00e7\u0131kmas\u0131 beklenen Covid-19 a\u015f\u0131lar\u0131 i\u00e7in de \u00f6nemli bir y\u0131l olacak.<\/span><\/div>\n

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Covid-19, Moderna (yaz\u0131l\u0131 kodu: MRNA), Pfizer (PFE) ve BioNTech’i (BNTX) bilinen isimler haline getirmeden \u00f6nce, yat\u0131r\u0131mc\u0131lar a\u015f\u0131 i\u015fine \u00e7ok az ilgi g\u00f6steriyordu. Bat\u0131 pazar\u0131na d\u00f6rt b\u00fcy\u00fck a\u015f\u0131 \u00fcreticisi hakimdi ve bozulma f\u0131rsatlar\u0131 marjinal g\u00f6r\u00fcn\u00fcyordu. Sekt\u00f6r hala eski a\u015f\u0131 santrallerinin hakimiyetindeyken, yat\u0131r\u0131mc\u0131lar art\u0131k daha yak\u0131ndan ilgileniyor. “Sokak s\u00f6z konusu oldu\u011funda [pandemi \u00f6ncesi] tipik olarak… b\u00fcy\u00fck \u00f6l\u00e7\u00fcde g\u00f6z ard\u0131 edilecek \u015feyler, \u015fimdi, son \u00fc\u00e7 y\u0131lda a\u015f\u0131lardan kazan\u0131lan dolarlarla, tekrar radardalar” diyor, Jared Holz, bir sa\u011fl\u0131k de\u011ferleme stratejisti. Sekt\u00f6r\u00fc yak\u0131ndan takip eden yat\u0131r\u0131mc\u0131lar i\u00e7in 2023’te neler izlenecek?<\/span><\/div>\n

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Ticari Covid-19 A\u015f\u0131lar\u0131<\/span><\/div>\n

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Salg\u0131n\u0131n ba\u015flang\u0131c\u0131ndan bu yana, federal h\u00fck\u00fcmet ABD’de da\u011f\u0131t\u0131lan t\u00fcm Kovid a\u015f\u0131 dozlar\u0131n\u0131 \u00f6dedi. A\u015f\u0131lar\u0131n ticari pazara girmesiyle bu durum gelecek y\u0131l de\u011fi\u015fecek.<\/span><\/div>\n
Pfizer, yeti\u015fkin dozu ba\u015f\u0131na 110 ila 130 ABD Dolar\u0131 aras\u0131nda \u00fccret almay\u0131 bekledi\u011fini s\u00f6ylerken, Moderna 64 ila 100 ABD Dolar\u0131 aras\u0131nda bir fiyattan bahsetti. Bu fiyatlar, \u015firketlerin ABD ve h\u00fck\u00fcmetten talep etti\u011fi oranlardan \u00e7ok daha y\u00fcksek – Pfizer’in g\u00fcncellenmi\u015f a\u015f\u0131s\u0131 i\u00e7in yakla\u015f\u0131k 30 dolar ve Modema’n\u0131n versiyonu i\u00e7in yakla\u015f\u0131k 26 dolar.<\/span><\/div>\n

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Pfizer, daha yerle\u015fik ticari altyap\u0131s\u0131 g\u00f6z \u00f6n\u00fcne al\u0131nd\u0131\u011f\u0131nda rekabet avantaj\u0131na sahip olabilir. Ancak pasta k\u00fc\u00e7\u00fcl\u00fcyor: FactSet’e g\u00f6re analistler, Pfizer’in Covid-19 a\u015f\u0131 sat\u0131\u015flar\u0131n\u0131n 2023’te kabaca yar\u0131 yar\u0131ya d\u00fc\u015ferek 17,2 milyar dolara ula\u015fmas\u0131n\u0131 bekliyor.<\/span><\/div>\n

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RSV A\u015f\u0131lar\u0131<\/span><\/div>\n

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RSV oranlar\u0131 bu sonbaharda y\u00fcksekti ve ayn\u0131 zamanda Covid-19 ve grip art\u0131\u015flar\u0131yla kar\u015f\u0131 kar\u015f\u0131ya kalan bir sa\u011fl\u0131k sistemi \u00fczerinde bask\u0131 olu\u015fturuyor.<\/span><\/div>\n
Pfizer ve GSK (GSK) k\u0131sa bir s\u00fcre \u00f6nce ilgili RSV a\u015f\u0131lar\u0131n\u0131n Faz 3 denemelerinden elde edilen etkileyici verileri duyurdu. Moderna ve Johnson & Johnson (JNJ) dahil olmak \u00fczere di\u011ferleri kendi RSV a\u015f\u0131lar\u0131 \u00fczerinde \u00e7al\u0131\u015f\u0131yor, ancak Pfizer ve GSK’n\u0131n pazara ilk girmesi bekleniyor.<\/span><\/div>\n

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RSV, sa\u011fl\u0131kl\u0131 yeti\u015fkinlerde normalde hafif semptomlara neden olan, ancak ya\u015fl\u0131 insanlar ve bebekler i\u00e7in ciddi ve hatta \u00f6l\u00fcmc\u00fcl olabilen yayg\u0131n bir vir\u00fcst\u00fcr. Pfizer ve GSK ya\u015fl\u0131 yeti\u015fkin pazar\u0131n\u0131 hedeflerken, Pfizer ayr\u0131ca yeni do\u011fan bebeklerini korumak i\u00e7in anne adaylar\u0131na uygulanacak bir versiyon haz\u0131rl\u0131yor.<\/span><\/div>\n
Pfizer ve GSK denemelerini kar\u015f\u0131la\u015ft\u0131rmak zordur, \u00e7\u00fcnk\u00fc RSV’nin neden oldu\u011fu ciddi hastal\u0131k tan\u0131mlar\u0131 biraz farkl\u0131d\u0131r, ancak her iki \u015firketin de sonu\u00e7lar\u0131 \u00fcmit verici g\u00f6r\u00fcnmektedir. GSK’n\u0131n etkinlik rakam\u0131 biraz daha y\u00fcksek g\u00f6r\u00fcn\u00fcyordu.<\/span><\/div>\n

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Ancak Pfizer y\u00f6neticileri, a\u015f\u0131 sat\u0131\u015f\u0131 s\u00f6z konusu oldu\u011funda GSK’y\u0131 geride b\u0131rakacaklar\u0131n\u0131 s\u00f6yl\u00fcyor. Pfizer CEO’su Albert Bourla, Kas\u0131m ay\u0131nda Barron’s’a \u201cBu pazarda lider olaca\u011f\u0131m\u0131z\u0131 d\u00fc\u015f\u00fcn\u00fcyorum\u201d dedi. Pfizer ayr\u0131ca a\u015f\u0131s\u0131n\u0131n daha iyi “tolere edilebilir” oldu\u011funu, yani a\u011fr\u0131 veya ate\u015f gibi k\u0131sa s\u00fcreli reaksiyon insidans\u0131n\u0131n\u00b2 daha d\u00fc\u015f\u00fck oldu\u011funu iddia ediyor.<\/span><\/div>\n

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Bu ay\u0131n ba\u015flar\u0131nda Pfizer, RSV a\u015f\u0131s\u0131n\u0131n 2027’de y\u0131ll\u0131k 2 milyar dolardan fazla gelir getirebilece\u011fini s\u00f6yledi.<\/span><\/div>\n

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GSK ise a\u015f\u0131s\u0131n\u0131n piyasadaki en iyi a\u015f\u0131 olabilece\u011fini s\u00f6yl\u00fcyor. GSK’n\u0131n a\u015f\u0131 Ar-Ge ba\u015fkan\u0131 Phil Dormitzer, “Sonu\u00e7 b\u00fcy\u00fckl\u00fc\u011f\u00fcm\u00fcz\u00fcn, 70 ila 79 ya\u015f aras\u0131 yeti\u015fkinler dahil olmak \u00fczere s\u00fcrekli y\u00fcksek etkinli\u011fimizin, iyi tolere edilebilirlik ve olumlu g\u00fcvenlik profilimizin, GSK RSV a\u015f\u0131s\u0131 aday\u0131na, s\u0131n\u0131f\u0131n\u0131n en iyisi potansiyeli verdi\u011fine inan\u0131yoruz” diyor.<\/span><\/div>\n

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FDA\u00b3, May\u0131s ay\u0131na kadar ya\u015fl\u0131 yeti\u015fkinler i\u00e7in a\u015f\u0131lardan birinin veya her ikisinin onaylan\u0131p onaylanmayaca\u011f\u0131na karar verecek. CDC\u2074’den gelen \u00f6neriler ve potansiyel bir sunum, ajans\u0131n a\u015f\u0131 dan\u0131\u015fmanlar\u0131n\u0131n Haziran ay\u0131nda yapacaklar\u0131 bir toplant\u0131dan sonra gelebilir. Ayr\u0131ca, paketin gerisinde kalsa da izlemeye de\u011fer: Moderna, 2023’\u00fcn ba\u015flar\u0131nda mRNA tabanl\u0131 RSV a\u015f\u0131s\u0131 hakk\u0131nda yeni veriler yay\u0131nlayabilir.<\/span><\/div>\n

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MRNA Bazl\u0131 Grip A\u015f\u0131lar\u0131<\/span><\/div>\n

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mRNA tabanl\u0131 Covid-19 a\u015f\u0131lar\u0131n\u0131n ba\u015far\u0131s\u0131n\u0131n ard\u0131ndan, mRNA tabanl\u0131 grip a\u015f\u0131lar\u0131 Big Pharma\u2075’da \u00e7ok reva\u00e7ta. Moderna’n\u0131n adaylar\u0131ndan biri olan mRNA-1010 i\u00e7in 2022’nin ba\u015flar\u0131nda yay\u0131nlanan ho-hum\u2076 performans verileri, ila\u00e7 \u015firketlerinin \u015fevkini k\u0131ramad\u0131.<\/span><\/div>\n

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Bug\u00fcn mRNA tabanl\u0131 grip a\u015f\u0131lar\u0131 Moderna, Pfizer ve Sanofi (SNY) taraf\u0131ndan geli\u015ftirilmektedir. Nihai hedef, grip, Covid-19 ve RSV dahil olmak \u00fczere birden fazla vir\u00fcse kar\u015f\u0131 koruma sa\u011flayan kombinasyon a\u015f\u0131lar geli\u015ftirmektir.<\/span><\/div>\n

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Moderna, 2023’\u00fcn ba\u015flar\u0131nda olmas\u0131 beklenen mRNA-1010 i\u00e7in Faz 3 verilerini bekliyor. \u015eirket, her \u015fey yolunda giderse, d\u00fczenleyici onaylar\u0131n o y\u0131l\u0131n sonuna kadar ba\u015flayabilece\u011fini s\u00f6yl\u00fcyor. Moderna CEO’su Stephane Bancel, bu ay\u0131n ba\u015flar\u0131nda Barron’s’a “Baz\u0131 \u00fclkeler ’23’te ba\u015flayabilir” dedi. “Balance[Denge, bilan\u00e7o] ’24’te ba\u015flayacak.”<\/span><\/div>\n

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Pfizer ayr\u0131ca 2024’te bir mRNA grip a\u015f\u0131s\u0131 piyasaya s\u00fcrmeyi bekledi\u011fini s\u00f6yl\u00fcyor. B\u00fcy\u00fck bir soru, \u015firketlerin yeni a\u015f\u0131lar\u0131 yakla\u015f\u0131k 15 dolara mal olan yerle\u015fik grip a\u015f\u0131lar\u0131yla rekabet edecek kadar ucuza fiyatland\u0131r\u0131p fiyatland\u0131ramayacaklar\u0131. Holz’a soruyor: “Gripli [mRNA] oyuncular\u0131 grip a\u015f\u0131s\u0131n\u0131 bu fiyata satabilecek mi veya satmaya istekli olacak m\u0131?”<\/span><\/div>\n<\/div>\n
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Kaynak: Barron’s – December 26, 2022 | English | 55 pages \/ pages: 13<\/span><\/div>\n
https:\/\/bit.ly\/3PTyUsP<\/a><\/span><\/div>\n

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Notlar: (Bu k\u0131s\u0131m T\u00fcrk\u00e7e \u00e7eviri i\u00e7in taraf\u0131mdan eklenmi\u015ftir)<\/span><\/div>\n
1) RSV: Respiratuvar Sinsitiyal Virus: RSV vir\u00fcs\u00fc yani Respiratuar Sinsisyal Vir\u00fcs; Grip ve so\u011fuk alg\u0131nl\u0131\u011f\u0131na benzer \u015fikayetlere neden olurken, tedavisinde gecikildi\u011finde akci\u011ferleri tehdit ediyor.<\/span><\/div>\n
2) incidence: Olu\u015f s\u0131kl\u0131\u011f\u0131<\/span><\/div>\n
3) FDA: U.S. Food and Drug Administration : FDA, Amerika Birle\u015fik Devletleri Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131na ba\u011fl\u0131; g\u0131da, g\u0131da takviyeleri, ila\u00e7, biyolojik medikal \u00fcr\u00fcnler, kan \u00fcr\u00fcnleri, medikal ara\u00e7lar, radyasyon yayan aletler, veteriner aletleri ve kozmetiklerden sorumlu b\u00fcrodur.<\/span><\/div>\n
4) CDC: Centers for Disease Control and Prevention: ABD Hastal\u0131k Kontrol ve Korunma Merkezleri <\/span><\/div>\n
5) Big Pharma: B\u00fcy\u00fck \u0130la\u00e7 Firmalar\u0131n\u0131 tan\u0131mlamak i\u00e7in kullan\u0131lan k\u0131saltma<\/span><\/div>\n
6) ho-hum: Rakiplerinkinden \u00f6nemli \u00f6l\u00e7\u00fcde ay\u0131rt edilemeyen yayg\u0131n, g\u00fcnl\u00fck e\u015fyalara (ata\u00e7, \u00e7izim i\u011fnesi, z\u0131mba teli ve karalama defteri gibi) at\u0131fta bulunmak i\u00e7in kullan\u0131lan konu\u015fma dilinde bir terim; ‘ho-hum’ \u00fcr\u00fcnlerini sat\u0131n alanlar genellikle mevcut en ucuz \u00fcr\u00fcn\u00fc tercih edecektir.<\/span><\/div>\n

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Bu yaz\u0131 25 Aral\u0131k 2022 tarihinde yaz\u0131lm\u0131\u015ft\u0131r. \u00c7eviri \u00e7al\u0131\u015fmas\u0131 tamamen amat\u00f6r bir u\u011fra\u015ft\u0131r ve bireysel kullan\u0131m i\u00e7in  yap\u0131lm\u0131\u015ft\u0131r.<\/u><\/b><\/span><\/div>\n<\/div>\n
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DERG\u0130 HAKKINDA<\/span><\/b><\/div>\n
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Barron’s<\/b> ABD’de yay\u0131mlanan haftal\u0131k borsa, finans, analiz dergisidir. \u015eirketlerden haberler, borsa <\/span>analizleri ve finans d\u00fcnyas\u0131ndaki son geli\u015fmeleri okuyucular\u0131na aktar\u0131yor.<\/span><\/div>\n

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Ben bu dergide iki yaz\u0131y\u0131 makine \u00e7evirisiyle okuyup anlamaya \u00e7al\u0131\u015ft\u0131m. Birincisi<\/span><\/div>\n
“Why 2023 Will Be a Huge Year for Vaccines” (2023 Neden A\u015f\u0131lar \u0130\u00e7in B\u00fcy\u00fck Bir Y\u0131l Olacak?), ikincisi ise<\/span><\/div>\n
“A Semiconductor Renaissance Is Under Way. It Will Change the World.” (Yar\u0131 \u0130letken R\u00f6nesans\u0131 S\u00fcr\u00fcyor. D\u00fcnyay\u0131 De\u011fi\u015ftirecek.”<\/span><\/div>\n

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2023 y\u0131l\u0131nda B\u00fcy\u00fck \u0130la\u00e7 \u015eirketleri aras\u0131nda \u00f6zellikle a\u015f\u0131lar konusunda ya\u015fanacak rekabet ve pazara <\/span>s\u00fcr\u00fclecek a\u015f\u0131lar hakk\u0131nda borsay\u0131 takip edenlere bilgi sa\u011fl\u0131yor. Hangi firma hangi a\u015f\u0131lar\u0131 \u00fcretecek ve  <\/span>2023’den beklentileri \u00fczerine bir yaz\u0131 yer al\u0131yor.<\/span><\/div>\n

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Yar\u0131 \u0130letkenler de di\u011fer \u00e7ok \u00f6nemli bir konu. \u00c7ip (yonga) yapan \u00fclkeler, kar\u015f\u0131la\u015f\u0131lan s\u0131k\u0131nt\u0131lar yeni pazarlar ve  sekt\u00f6re yeni girecek \u00fclkeler ile ilgili bir analiz yap\u0131l\u0131yor.<\/span><\/div>\n

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Bu iki yaz\u0131y\u0131 da makine \u00e7evirisi ve ayr\u0131ca d\u00fczenleme yaparak buraya ekledim. Anla\u015f\u0131lmayan bir yer ya da di\u011fer hususlar i\u00e7in esas metin \u0130ngilizceden yard\u0131m al\u0131nabilir. \u00c7eviri \u00e7al\u0131\u015fmas\u0131 tamamen amat\u00f6r bir u\u011fra\u015ft\u0131r ve bireysel kullan\u0131m i\u00e7in  yap\u0131lm\u0131\u015ft\u0131r.<\/u><\/b><\/span><\/div>\n

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Derginin kapa\u011f\u0131nda ise “Robots Are Replacing Workers Lost in the Pandemic. They\u2019re Here to Stay. <\/span>(Pandemide Kaybolan \u0130\u015f\u00e7ilerin Yerine Robotlar Geliyor. Kalmak \u0130\u00e7in Buradalar.) ba\u015fl\u0131\u011f\u0131 ile gelece\u011fe <\/span>bir projeksiyon tutuyor.<\/span><\/div>\n<\/div>\n
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  Vaccines Could Be Even Bigger in 2023 (A\u015f\u0131lar 2023’te Daha da B\u00fcy\u00fcyebilir) Wall Street, salg\u0131n vurana kadar a\u015f\u0131 pazar\u0131n\u0131 b\u00fcy\u00fck \u00f6l\u00e7\u00fcde g\u00f6rmezden geldi. Bu y\u0131l, a\u015f\u0131lar\u0131n Covid-19 ile sava\u015fmaktan daha fazlas\u0131 oldu\u011funu g\u00f6sterecek. JOSH NATHAN-KAZIS Salg\u0131n\u0131n Wall Street’i a\u015f\u0131lardaki f\u0131rsatlara uyand\u0131rmas\u0131ndan bu yana \u00fc\u00e7 y\u0131l ge\u00e7ti. Yat\u0131r\u0131mc\u0131lar\u0131n i\u011fne cephesinde daha fazla b\u00fcy\u00fck haber aramas\u0131n\u0131n… Daha fazlas\u0131n\u0131 oku »Barron’s – December 26, 2022<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","_ti_tpc_template_sync":false,"_ti_tpc_template_id":"","footnotes":""},"categories":[314,313,309,310,315,311,312],"tags":[640,639],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/kesikkalem.com\/index.php\/wp-json\/wp\/v2\/posts\/68"}],"collection":[{"href":"https:\/\/kesikkalem.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kesikkalem.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kesikkalem.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kesikkalem.com\/index.php\/wp-json\/wp\/v2\/comments?post=68"}],"version-history":[{"count":1,"href":"https:\/\/kesikkalem.com\/index.php\/wp-json\/wp\/v2\/posts\/68\/revisions"}],"predecessor-version":[{"id":227,"href":"https:\/\/kesikkalem.com\/index.php\/wp-json\/wp\/v2\/posts\/68\/revisions\/227"}],"wp:attachment":[{"href":"https:\/\/kesikkalem.com\/index.php\/wp-json\/wp\/v2\/media?parent=68"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kesikkalem.com\/index.php\/wp-json\/wp\/v2\/categories?post=68"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kesikkalem.com\/index.php\/wp-json\/wp\/v2\/tags?post=68"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}